Basal ganglia image

ObjectivesTo measure iron accumulation in the basal ganglia in Huntington's disease (HD) using quantitative susceptibility mapping (QSM), and to ascertain its relevance in terms of clinical and disease severity.
Methods In this cross-sectional investigation, weighted imaging was undertaken on 31 premanifest HD, 32 symptomatic HD and 30 control participants as part of the observational IMAGE-HD study. Group differences in iron accumulation were ascertained with QSM. Associations between susceptibility values and disease severity were also investigated.
Results Compared with controls, both premanifest and symptomatic HD groups showed significantly greater iron content in pallidum, putamen and caudate. Additionally, iron accumulation in both putamen and caudate was significantly associated with disease severity.
Conclusions These findings provide the first evidence that QSM is sensitive to iron deposition in subcortical target areas across premanifest and symptomatic stages of HD. Such findings could open up new avenues for biomarker development and therapeutic intervention.
You might also like




Organic Our Baby Aloe Eczema & Psoriasis Cream, Body & Face Cream, Lotion for Sensitive Skin, Natural Healing Power of Shea Butter, Jojoba, MSM, Apricot, Vitamins, Essential Oils & Amino Acids, Big 9 Ounce Container,, Instant Itch Relief Beauty (Reliable Quality Products)
|
![]() |
Hyaluronic Acid Cream Moisturizer Face and Skin with Squalane, Jojoba and Apricot Oil, Airless Jar Protects Formula, Best Anti Aging Moisturizer, 1 Oz Beauty ()
|