HBM Journal

Effect of activating Lrp5 NeoR-containing HBM alleles.() Graphs depicting femoral and vertebral trabecular BV/TV in WT mice and in mice with Lrp5 NeoR-containing HBM alleles. (b, c) Graphs depicting femoral trabecular BV/TV (b) and vertebral trabecular BV/TV (c) in mice with (shaded bars) and without (unshaded bars) inherited NeoR-containing Lrp5 HBM alleles (+/AN or +/GN, and +/A or +/G, respectively), and with and without Vil1-Cre (+V and –V, respectively) or Dmp1-Cre (+D and –D, respectively) transgenes. () Photographs of agarose gels containing PCR amplimers derived from mouse genomic DNA extracted from either duodenum or femur cortex of mice with different Lrp5 and Cre-transgene genotypes. PCR amplimers correspond to the sizes depicted in Figure 1a. Top, amplimers from the Dmp1-Cre cross. Bottom, amplimers from the Vil1-Cre cross. WT allele (arrowheads), AN or GN allele (double arrowheads) A or G allele (arrows). (e) Graphs depicting fluorochrome-derived bone formation parameters in the distal femur from 9-week-old female mice that were administered double calcein labeling. Group notations ( axis) follow those described for panel b. () Graphs depicting the proportion of distal femur trabecular bone surface covered by osteoclasts (Oc.S; left) and osteoblasts (Ob.S; right). (g) Graphs depicting femoral and vertebral trabecular BV/TV in 12-week-old mice with (shaded bars) and without (unshaded bars) inherited NeoR-containing Lrp5 HBM alleles (+/AN and +/A), respectively, and with and without the Prrx1-Cre transgene (+P and −P, respectively). MS/BS, MAR, BFR/BS are as defined in Figure 1. The numbers of mice studied are indicated. Error bars show means ± s.d. * < 0.05 versus NeoR-containing littermates that did not inherit a Cre transgene.

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