Mental Status Examination Form

Hallucination; 50

Dementia is an acquired clinical syndrome that associates memory decline and at least one other cognitive function decline, all disturbing social or daily living activities . An estimated 50% of patients over 65 are not diagnosed by their primary care physician, and most missed cases are mild to moderate [, ]. As yearly incidence of dementia increases with age, the under-diagnosis of dementia in primary care will probably increase in the future . This under-diagnosis is in part related to a limited time for in-depth consideration of cognitive difficulties of primary care patients [–].

Since 2003, the U.S. preventive services task force highlighted that the Mini-Mental State Examination (MMSE) was the best-studied instrument to screen cognitive impairment in selected patients with cognitive impairment . This test is scored out of 30, a score of 24 or less suggesting dementia [–]. Although the MMSE is the most widely used screening test in specialized clinical setting, it is little used by primary care physicians because it is time-consuming (e.g.; around 20 minutes to perform), and is thus hardly practicable during routine office visits . Several short screening tests for dementia have been developed but their positive predictive values (PPV) were low, calculated around 50% . Therefore, for dementia screening, primary care physicians need a brief and accurate screening test, applicable during clinical practice among patients with cognitive complaint.

Episodic memory is a memory system that enables individuals to remember events, times and places acquired through personal experience. Episodic memory impairment is the most frequent symptom of dementia and the most common complaint [–]. A brief cognitive test based on the evaluation of episodic memory impairment with sufficient sensitivity, specificity and predictive values could therefore serve as a useful screening tool for dementia. Among the 30 items of the MMSE that address multiple cognitive domains, 6 items specifically assessing episodic memory can be fortunately distinguished . The time needed to complete these 6 episodic memory items is much shorter compared to the 30 items of the whole MMSE. What is more, since MMSE is widely used for a long time all over the world [–], physicians usually know it and the way to use it. These two points suggest that a short test based on the 6 episodic memory items of the MMSE would be easily used by physicians to detect dementia. Its accuracy remains yet to be determined. We hypothesized that the 6 memory items of the MMSE could be used alone to build a Short form of Mini-Mental State Examination (SMMSE) with sufficient sensitivity, specificity, positive and negative predictive values to serve as a good screening test for dementia in older adults with memory complaint. The aim of this study was to determine whether the SMMSE was as accurate as the MMSE in screening dementia among older ambulatory participants with a memory complaint.


Our results showed that the SMMSE score was strongly associated with the diagnosis of dementia. In addition, a score ≤ 4 of SMMSE had a higher specificity, PPV, NPV, positive and negative LR than a MMSE score ≤ 24.

The SMMSE appears to be a good new screening test for dementia among older adults presenting with a memory complaint. We showed a strong association between a score ≤ 4 and dementia which is in concordance with previous studies reporting that memory tests had a high discriminative validity for dementia [–, ]. AD has been identified as the most prevalent dementia in older adults, which was the case in our studied sample . Because memory impairments are highly prevalent in AD, it is not surprising that a test based on memory may screen dementia with a high predictive value [, ]. However, compared to previous studies, SMMSE did not use an encoding specificity because it follows the instructions of assessment of MMSE [–, ]. SMMSE thus assesses not only episodic memory (encoding and retrieval phase) but also semantic memory, attention and probably executive functions deficit.

In clinical practice, when older patients present with a memory complaint, the first issue is to make a diagnosis and determine whether they are demented or not. A screening test able to identify patient who have dementia is therefore of prime importance for daily practice [, ]. Discriminative validity of SMMSE for dementia was high compared to MMSE in our study. In addition, unlike previous short screening tests for dementia, SMMSE had a higher PPV than MMSE calculated at 95.5 . The SMMSE could thus be used in clinical practice as an efficient screening test for dementia in older adults with a memory complaint.

The second issue in primary care settings is related to the under-diagnosis of dementia [–]. Several explanations account for this problem which is not only due to the lack of diagnostic skill, but rather to a pressure on time . Because MMSE takes up to 20 minutes to complete, it may not be practical in primary care practice. In contrast, SMMSE is shorter to perform, easier and more accessible compared to MMSE. As a consequence, SMMSE could be proposed to general practitioners as a fast screening tool for dementia.

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