Human brain MRI

Mri Scan Of Human Brain Stock

Early in Alzheimer’s, connections between neurons begin to wither and die. One of the defining features of AD, this synapse loss underlies cognitive impairment, but has proven hard to track in the living brain. A paper in the July 20 Science Translational Medicine may change that. Scientists led by Richard Carson and Sjoerd Finnema at Yale University in New Haven, Connecticut, report on a positron emission tomography (PET) tracer that binds to a protein on presynaptic vesicles, revealing the density of synapses throughout the brain. In healthy people, the compound entered the brain quickly and bound predominantly gray matter. In epilepsy patients, it picked up areas of synaptic loss near the focal point of seizures.

“This paper shows what appears to be the first radioligand to bind to sites at synapses in the brain, ” wrote Richard Mohs, Global Alzheimer’s Platform Foundation, to Alzforum. If confirmed, this could provide a way to measure synaptic density in living people and track changes in density regionally and with disease, he added. “These scans would complement other newly developed radioligands that allow imaging of amyloid plaques, neurofibrillary tangles, and other types of brain pathology.”

Synaptic signal. [11C]UCB-J binds synapses and lights up in a PET scan of a healthy subject. [Science Translational Medicine/AAAS.]

Until now, researchers could only measure synaptic density in postmortem tissue by using antibodies to detect proteins such as synaptophysin (Buckley and Kelly, 1985). A molecule that binds synaptophysin might prove useful as a PET ligand but scientists have yet to find one. However, levetiracetam—an anti-epileptic drug—targets a similarly widespread protein called synaptic vesicle glycoprotein 2A (SV2A). Previous studies have reported that every synaptic vesicle in the brain carries two to five copies of this protein, said Finnema. UCB, the Brussels-based company that developed levetiracetam and provided some of the funding for this study, derived several PET tracer candidates based on this drug. A couple have been tested in animals and humans, but no reports on human brain imaging had been published (Estrada et al., 2016; Bretin et al., 2015). Carson, who directs the Yale PET Center, which specializes in developing and using new PET ligands, chose one of the derivatives, [11C]UCB-J, to test in people.

You might also like

The Teenage Brain Explained
The Teenage Brain Explained
The Human Brain Project SP 9: Neuromorphic Computing Platform
The Human Brain Project SP 9: Neuromorphic Computing Platform
How does the brain change with age? Part #1 Cam-CAN
How does the brain change with age? Part #1 Cam-CAN ...
How the Human Body Works - Kids Animation Learn Series
How the Human Body Works - Kids Animation Learn Series
Pure DHEA (100mg Max Strength, 200 Capsules) to Promote Balanced Hormone Levels for Women & Men - Natural DHEA Supplement Pills to Support Healthy Metabolism, Libio, Brain, Immune Function & Energy
Health and Beauty (aSquared Brands)
  • MAXIMUM STRENGTH DHEA (100 MG PER CAPSULE): DHEA (dehydroepiandrosterone) is a natural hormone that is produced by the adrenal glands. DHEA levels peak in your late...
  • FORMULATED FOR SUPERIOR RESULTS: With 100mg of DHEA per Capsule, our formula is designed to help restore optimal DHEA levels. Restoring balanced DHEA hormone levels...
  • BEST VALUE AVAILABLE ON AMAZON: Our maximum strength formula is MADE IN THE USA in a GMP compliant facility. Each bottle of our DHEA 100 MG formula contains 200...
  • HIGHEST QUALITY - 100% MONEY BACK GUARANTEE: Rest assured that we use the highest quality ingredients and our products go through stringent quality control testing...
  • PROVEN TRACK RECORD: aSquared Nutrition prides themselves on quality and reliability. We know you ll love our ever-expanding product line. We have a great selection...
Smart Connect Human Anatomy Test Free
Mobile Application (Smart Connect)
  • An admirable quiz app for all riddles and puzzles lovers;
  • Plenty of varied questions will make your memory training process amazingly interesting;
  • Comfortable interface;
The Human Body & The Human Brain: A Fascinating Book Containing Human Body & Brain Facts, Trivia, Images & Memory Recall Quiz: Suitable for Adults & Children (Matthew Harper)
Book (CreateSpace Independent Publishing Platform)
NootropX Advanced Nootropic Supplement (60 Capsules) - Gingko Biloba, L-Theanine, Ginseng - Enhanced Mental Acuity Including Focus, Memory, Clarity and Concentration - Brain and Cognitive Development
Health and Beauty (Neuro Research Institute)
  • FASTER, CLEARER COGNITIVE FUNCTION - NootropX is a scientifically-formulated brain booster that helps improve your focus, clarity, natural alertness, and overall...
  • SAFE, POWERFUL, NATURAL ENERGY - Packed with natural vitamins, nutrients and minerals, we help you achieve limitless brain potential without the jitters or negative...
  • IMPROVED SHORT & LONG-TERM MEMORY - NootropX s powerful formula also helps fortify your brain s ability to retain and relay information by stimulating brain...
  • STAY AT PEAK PERFORMANCE - Enhanced cognitive function extends far beyond focus and clarity, it can also lead to improved performance at work, school, or the gym...
  • NO HASSLE, RISK FREE GUARANTEE - We ve worked hard to create the best nootropic available, which is why it s backed by a satisfaction guarantee. If you try NootropX...
Rockred Brain Fitness Maximize Your Brain Power and Memory
Mobile Application (Rockred)
  • Neuroscientists believed that humans were born with a certain number of neurons that die little by little with age. When a neuron dies, it is lost permanently. However...
  • It is a simple fact that the human brain changes as a person ages. Over time, our brain s volume and weight diminishes. As a matter of fact, we lose ten percent...
  • The way we live, what we eat, our habits and every part of our lifestyle are major culprits too. Bad habits including poor diet, lack of exercise, alcohol drinking...
  • The question now is: what are we going to do about it?


When was the Right Brain Initiative established?

The Right Brain Initiative is a non-profit that was created to increase youth participation in the arts in the state of Oregon. It was established in 2008.

Copyright © . All Rights Reserved